Quantification of edema reduction using differential quantitative T2 (DQT2) relaxometry mapping in recurrent glioblastoma treated with bevacizumab
نویسندگان
چکیده
منابع مشابه
Neurocognitive function in patients with recurrent glioblastoma treated with bevacizumab.
Neurocognitive decline is a frequent adverse effect of glioblastoma. Antitumor therapies that are efficacious, as measured by traditional endpoints such as objective response (OR) and progression-free survival (PFS), and have beneficial effects on neurocognitive function (NCF) are of clinical benefit to these patients. We evaluated neurocognitive changes across time in 167 patients with recurre...
متن کاملQuantitative volumetric analysis of conventional MRI response in recurrent glioblastoma treated with bevacizumab.
Although the effects of bevacizumab on magnetic resonance images (MRIs) of recurrent glioblastoma multiforme (GBM) are well documented, to our knowledge, no studies have explicitly quantified the volumetric changes resulting from initial treatment, nor have there been studies examining the ability for volumetric changes in conventional MRI to predict progression-free survival (PFS) and overall ...
متن کاملQuantitative T2 mapping of recurrent glioblastoma under bevacizumab improves monitoring for non-enhancing tumor progression and predicts overall survival.
BACKGROUND Anti-angiogenic treatment in recurrent glioblastoma patients suppresses contrast enhancement and reduces vasogenic edema while non-enhancing tumor progression is common. Thus, the importance of T2-weighted imaging is increasing. We therefore quantified T2 relaxation times, which are the basis for the image contrast on T2-weighted images. METHODS Conventional and quantitative MRI pr...
متن کاملHigh-resolution quantitative 3D T2 mapping allows quantification of changes in edema after myocardial infarction
Background T2 values are related to the tissue water content, providing useful diagnostic information in cardiac diseases, especially in acute states such as myocardial infarction (MI). Visualization of edema, its regional distribution, and extent in acute and chronic heart disease may be useful as a diagnostic tool and help in guiding treatment in the patients with heart disease. Recently, ede...
متن کاملThe Impact of T2/FLAIR Evaluation per RANO Criteria on Response Assessment of Recurrent Glioblastoma Patients Treated with Bevacizumab.
PURPOSE The RANO criteria have not been assessed using outcome data from prospective trials. We examined the radiologic data of patients with recurrent glioblastoma from the randomized phase II trial (AVF3708g) to determine the effect of including T2/FLAIR evaluation as per RANO criteria on measurements of objective response rates (ORRs) and progression-free survival (PFS) compared with assessm...
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ژورنال
عنوان ژورنال: Journal of Neuro-Oncology
سال: 2011
ISSN: 0167-594X,1573-7373
DOI: 10.1007/s11060-011-0638-x